The proMMP-2 activation rate in patients with chronic viral liver disease

被引：5

作者：

Murawaki, Y ^{[1
]}

Ikuta, Y ^{[1
]}

Koda, M ^{[1
]}

Okamoto, K ^{[1
]}

Mimura, K ^{[1
]}

机构：

[1] Tottori Univ, Sch Med, Dept Internal Med 2, Yonago, Tottori 6838504, Japan

来源：

CLINICA CHIMICA ACTA | 2002年 / 324卷 / 1-2期

关键词：

active MMP-2; proMMP-2; TIMP-2; activation; liver disease;

D O I：

10.1016/S0009-8981(02)00239-5

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: We previously showed that serum promatrix metalloproteinase-2 (proMMP-2) concentrations were increased in cirrhotic patients, reflecting the increase in liver proMMP-2 concentrations. We examined whether the increased proMMP-2 concentration reflects the biological matrix metalloproteinase-2 (MMP-2) activity. Methods: We measured serum concentrations of active MMP-2 and proMMP-2, and calculated the active MMP-2/proMMP-2 ratio as an index of the proMMP-2 activation rate in chronic viral liver disease. Results: The serum active MMP-2 concentrations were not altered in chronic liver disease, although the serum proMMP-2 concentration was markedly increased in cirrhotic patients. The active MMP-2/proMMP-2 ratio decreased with the grade of liver fibrosis, and was negatively correlated with serum levels of tissue inhibitor of metalloproteinases (TIMP)-2. Conclusion: The proMMP-2 activation rate may be inhibited by the increased TIMP-2 in liver cirrhosis (LC), resulting in the accumulation of basement membrane collagens. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：99 / 103

页数：5

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