Intramolecular carbolithiation of N-allyl-N-2-lithioallylamines:: effect of the allyl moiety

被引：5

作者：

Barluenga, J

Fañanás, FJ

Sanz, R

Fernández, Y

机构：

[1] CSIC, Unidad Asociada, Inst Quim Organomet Enrique Moles, Oviedo 33071, Spain

[2] Univ Burgos, Fac Ciencias, Area Quim Organ, Dept Quim, Burgos 09001, Spain

来源：

COMPTES RENDUS CHIMIE | 2004年 / 7卷 / 8-9期

关键词：

organolithium compounds; carbolithiation; pyrrolidines; hexahydroindoles;

D O I：

10.1016/j.crci.2004.02.015

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The preparation of new N-2-bromoallyl-N-(3-functionalized)allylamines and the intramolecular carbolithiation reactions of the corresponding organolithiums generated by bromine-lithium exchange are reported. The effect of the substituent at the terminal position of the allyl moiety is studied. This methodology allows the efficient synthesis of a variety of interesting functionalized pyrrolidine and hexahydroindole derivatives from simple starting materials. (C) 2004 Academie des sciences. Published by Elsevier SAS. All rights reserved.

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收藏

页码：855 / 864

页数：10

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