Basic fibroblast growth factor modulates synaptic transmission in cultured rat hippocampal neurons

被引:18
作者
Tanaka, T [1 ]
Saito, H [1 ]
Matsuki, N [1 ]
机构
[1] UNIV TOKYO,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL,BUNKYO KU,TOKYO 113,JAPAN
关键词
basic fibroblast growth factor; synaptic transmission; synaptic modulation; intracellular calcium oscillation; GABAergic system;
D O I
10.1016/0006-8993(96)00245-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Basic fibroblast growth factor (bFGF) is one of the effective growth factors that protect neurons against excitotoxic/ischemic injury and promote neuronal survival. In the present study, we examined the acute modulative effect of bFGF on synaptic transmission by monitoring spontaneous intracellular Ca2+ ([Ca2+]i) oscillation, the amplitudes of which reflect excitatory and inhibitory inputs. The hippocampal cells from embryonic day 18 rats were cultured for 11-14 days, and changes in [Ca2+]i of single neurons were measured by a microfluometrical technique with fura-2. The amplitude of spontaneous oscillation was decreased by 10 ng/ml bFGF, but not by nerve growth factor (10-1000 ng/ml). Acidic FGF (1000 ng/ml)had a weaker depressant effect. The effect of bFGF was counteracted by suramin. bFGF did not affect the increase in [Ca2+]i evoked by glutamate agonists, NMDA or kainate, indicating that glutamate receptors are not involved in the mechanism. This is supported by similar results that kainate-evoked current was not affected by bFGF. On the other hand, bicuculline masked the effect of bFGF on the Ca2+ oscillation. But GABA-evoked current was slightly decreased by bFGF. These results suggest the possible role of bFGF in modulating GABAergic rather than glutamatergic neurotransmission.
引用
收藏
页码:190 / 195
页数:6
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