Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014

被引：72

作者：

Feikin, Daniel R. ^{[1
]}

Alraddadi, Basem ^{[2
,3
]}

Qutub, Mohammed ^{[2
,3
]}

Shabouni, Omaima ^{[2
]}

Curns, Aaron ^{[1
]}

Oboho, Ikwo K. ^{[1
]}

Tomczyk, Sara M. ^{[1
]}

Wolff, Bernard ^{[1
]}

Watson, John T. ^{[1
]}

Madani, Tariq A. ^{[2
,4
]}

机构：

[1] Ctr Dis Control & Prevent, Atlanta, GA USA

[2] Minist Hlth, Jeddah, Saudi Arabia

[3] King Faisal Specialist Hosp & Res Ctr, Jeddah, Saudi Arabia

[4] King Abdulaziz Univ, Jeddah 21413, Saudi Arabia

来源：

EMERGING INFECTIOUS DISEASES | 2015年 / 21卷 / 11期

关键词：

EAST RESPIRATORY SYNDROME; SYNDROME CORONAVIRUS INFECTION; SYNCYTIAL VIRUS; CLINICAL-COURSE; INFLUENZA; OUTCOMES; VALUES;

D O I：

10.3201/eid2111.150764

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Middle East respiratory syndrome coronavirus (MERS-CoV) causes a spectrum of illness. We evaluated whether cycle threshold (C-t) values (which are inversely related to virus load) were associated with clinical severity in patients from Saudi Arabia whose nasopharyngeal specimens tested positive for this virus by real-time reverse transcription PCR. Among 102 patients, median C-t of 31.0 for the upstream of the E gene target for 41(40%) patients who died was significantly lower than the median of 33.0 for 61 survivors (p =, 0.0087). In multivariable regression analyses, risk factors for death were age >60 years, underlying illness, and decreasing C-t. Results were similar for a composite severe outcome (death and/or intensive care unit admission). More data are needed to determine whether modulation of virus load by therapeutic agents affects clinical outcomes.

引用

页码：2029 / 2035

页数：7

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