Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

被引：1257

作者：

Morel, Anne-Pierre ^{[1
]}

Lievre, Marjory ^{[1
]}

Thomas, Clemence ^{[1
,2
]}

Hinkal, George ^{[1
,2
]}

Ansieau, Stephane ^{[1
,2
]}

Puisieux, Alain ^{[1
,2
,3
]}

机构：

[1] Ctr Leon Berard, F-69373 Lyon, France

[2] Inserm, U590, Lyon, France

[3] Univ Lyon, ISPB, Lyon, France

来源：

PLOS ONE | 2008年 / 3卷 / 08期

关键词：

D O I：

10.1371/journal.pone.0002888

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recently, two novel concepts have emerged in cancer biology: the role of so-called "cancer stem cells'' in tumor initiation, and the involvement of an epithelial-mesenchymal transition (EMT) in the metastatic dissemination of epithelial cancer cells. Using a mammary tumor progression model, we show that cells possessing both stem and tumorigenic characteristics of "cancer stem cells'' can be derived from human mammary epithelial cells following the activation of the Ras-MAPK pathway. The acquisition of these stem and tumorigenic characters is driven by EMT induction.

引用

页数：7

共 40 条

[31] CD44+/CD24- breast cancer cells exhibit enhanced invasive properties:: an early step necessary for metastasis
Sheridan, Carol
Kishimoto, Hiromitsu
Fuchs, Robyn K.
Mehrotra, Sanjana
Bhat-Nakshatri, Poornima
Turner, Charles H.
Goulet, Robert, Jr.
Badve, Sunil
Nakshatri, Harikrishna
[J]. BREAST CANCER RESEARCH, 2006, 8 (05):
[32] Molecular definition of breast tumor heterogeneity
Shipitsin, Michail
Campbell, Lauren L.
Argani, Pedram
Werernowicz, Stanislawa
Bloushtain-Qimron, Noga
Yao, Jun
Nikolskaya, Tatiana
Serebryiskaya, Tatiana
Beroukhim, Rameen
Hu, Min
Halushka, Marc K.
Sukumar, Saraswati
Parker, Leroy M.
Anderson, Karen S.
Harris, Lyndsay N.
Garber, Judy E.
Richardson, Andrea L.
Schnitt, Stuart J.
Nikolsky, Yuri
Gelman, Rebecca S.
Polyak, Kornelia
[J]. CANCER CELL, 2007, 11 (03) : 259 - 273
[33] Identification of human brain tumour initiating cells
Singh, SK
Hawkins, C
Clarke, ID
Squire, JA
Bayani, J
Hide, T
Henkelman, RM
Cusimano, MD
Dirks, PB
[J]. NATURE, 2004, 432 (7015) : 396 - 401
[34] MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice
So, CW
Karsunky, H
Passegué, E
Cozzio, A
Weissman, IL
Cleary, ML
[J]. CANCER CELL, 2003, 3 (02) : 161 - 171
[35] Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells
Suetsugi, Atsushi
Nagaki, Masahito
Aoki, Hitomi
Motohashi, Tsutomu
Kunisada, Takahiro
Moriwaki, Hisataka
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 351 (04) : 820 - 824
[36] Epithelial-mesenchymal transitions in tumour progression
Thiery, JP
[J]. NATURE REVIEWS CANCER, 2002, 2 (06) : 442 - 454
[37] HIGHLY PURIFIED PRIMITIVE HEMATOPOIETIC STEM-CELLS ARE PML-RARA NEGATIVE AND GENERATE NONCLONAL PROGENITORS IN ACUTE PROMYELOCYTIC LEUKEMIA
TURHAN, AG
LEMOINE, FM
DEBERT, C
BONNET, ML
BAILLOU, C
PICARD, F
MACINTYRE, EA
VARET, B
[J]. BLOOD, 1995, 85 (08) : 2154 - 2161
[38] Direct isolation of human central nervous system stem cells
Uchida, N
Buck, DW
He, DP
Reitsma, MJ
Masek, M
Phan, TV
Tsukamoto, AS
Gage, FH
Weissman, IL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (26) : 14720 - 14725
[39] Vermeulen L, 2008, CELL DEATH DIFFER
[40] CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity
Yin, Shengyong
Li, Jinjun
Hu, Chen
Chen, Xinhua
Yao, Ming
Yan, Mingxia
Jiang, Guoping
Ge, Chao
Xie, Haiyang
Wan, Dafang
Yang, Shengli
Zheng, Shusen
Gu, Jianren
[J]. INTERNATIONAL JOURNAL OF CANCER, 2007, 120 (07) : 1444 - 1450

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