Visceral perception: inflammatory and non-inflammatory mediators

被引：94

作者：

Bueno, L ^{[1
]}

Fioramonti, J ^{[1
]}

机构：

[1] INRA, Dept Neurogastroenterol & Nutr, Neurogastroenterol Unit, F-31931 Toulouse 9, France

来源：

GUT | 2002年 / 51卷

关键词：

D O I：

10.1136/gut.51.suppl_1.i19

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Visceral hypersensitivity is currently the most widely accepted mechanism responsible for abdominal pain. Inflammatory mediators are known to sensitise primary afferents and to recruit silent nociceptors. Recent evidence suggests that non-inflammatory mediators also have the potential to trigger visceral pain. This sequence of events may constitute part of an alerting system which prompts the central nervous system to correct gastrointestinal responses to ingestion.

引用

页码：I19 / I23

页数：5

共 35 条

[1] Chronic low-level administration of diquat increases the nociceptive response to gastric distension in rats: role of mast cells and tachykinin receptor activation [J].

Anton, PM ;

Theodorou, V ;

Fioramonti, J ;

Bueno, L .

PAIN, 2001, 92 (1-2) :219-227

[2]

BATHON JM, 1991, ANNU REV PHARMACOL, V31, P129

[3]

BERNSTEIN CN, 1993, GASTROENTEROLOGY, V104, pA477

[4] THE NONPEPTIDE NK1 RECEPTOR ANTAGONIST, (+/-)-CP-96,345, PRODUCES ANTINOCICEPTIVE AND ANTI-EDEMA EFFECTS IN THE RAT [J].

BIRCH, PJ ;

HARRISON, SM ;

HAYES, AG ;

ROGERS, H ;

TYERS, MB .

BRITISH JOURNAL OF PHARMACOLOGY, 1992, 105 (03) :508-510

[5] Intracolonic glycerol induces abdominal contractions in rats:: Role of 5-HT3 receptors [J].

Botella, A ;

Fioramonti, J ;

Eeckhout, C ;

Bueno, L .

FUNDAMENTAL & CLINICAL PHARMACOLOGY, 1998, 12 (06) :619-623

[6] Effect of ovarian hormones on intestinal mast cell reactivity to Substance P [J].

Bradesi, S ;

Eutamene, H ;

Theodorou, V ;

Fioramonti, J ;

Bueno, L .

LIFE SCIENCES, 2001, 68 (09) :1047-1056

[7] Pathobiology of visceral pain:: Molecular mechanisms and therapeutic implications III.: Visceral afferent pathways:: a source of new therapeutic targets for abdominal pain [J].

Buéno, L ;

Fioramonti, J ;

Garcia-Villar, R .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2000, 278 (05) :G670-G676

[8]

Carstens E, 1995, NEWS PHYSIOL SCI, V10, P260

[9] Mast cell degranulation induces delayed rectal allodynia in rats - Role of histamine and 5-HT [J].

Coelho, AM ;

Fioramonti, J ;

Bueno, L .

DIGESTIVE DISEASES AND SCIENCES, 1998, 43 (04) :727-737

[10] Systemic lipopolysaccharide influences rectal sensitivity in rats:: role of mast cells, cytokines, and vagus nerve [J].

Coelho, AM ;

Fioramonti, J ;

Buéno, L .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2000, 279 (04) :G781-G790

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