Total serum IgE is associated with asthma independently of specific IgE levels

被引：142

作者：

Sunyer, J ^{[1
]}

Anto, JM ^{[1
]}

Castellsague, J ^{[1
]}

Soriano, JB ^{[1
]}

Roca, J ^{[1
]}

MartinezMoratalla, J ^{[1
]}

Almar, E ^{[1
]}

Arevalo, M ^{[1
]}

Mateos, A ^{[1
]}

Sanchez, A ^{[1
]}

Vizcaya, M ^{[1
]}

Burgos, F ^{[1
]}

Galobardes, MB ^{[1
]}

Tobias, A ^{[1
]}

Muniozguren, N ^{[1
]}

Errazola, M ^{[1
]}

Capelastegui, A ^{[1
]}

Ramos, J ^{[1
]}

Maldonado, JA ^{[1
]}

Sanchez, JL ^{[1
]}

Pereira, A ^{[1
]}

Gravalos, J ^{[1
]}

Quiros, R ^{[1
]}

Azofra, J ^{[1
]}

Palenciano, L ^{[1
]}

Payo, F ^{[1
]}

Rego, G ^{[1
]}

Vega, A ^{[1
]}

机构：

[1] HOSP CLIN BARCELONA,SERV PNEUMOL & ALLERGIA RESP,BARCELONA,SPAIN

来源：

EUROPEAN RESPIRATORY JOURNAL | 1996年 / 9卷 / 09期

关键词：

allergens; asthma; atopy; bronchial responsiveness; specific serum immunoglobulin E; total serum immunoglobulin E;

D O I：

10.1183/09031936.96.09091880

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

In this study we aimed to assess whether the association between asthma (defined by symptoms and bronchial responsiveness) and total immunoglobulin E (IgE) levels was independent of specific IgE level to common aeroallergens. A general population-based sample, supplemented with symptomatic individuals, comprising 1,916 young adults, aged 20-44 years, from five areas of Spain, performed a face-to-face respiratory questionnaire, and spirometry, and had total and specific serum IgE levels to mites, pets and moulds recorded. fn 1,626 of the subjects, a dose-response methacholine challenge test was completed. Subjects reporting current attacks of asthma showed an association with total IgE (odds ratio (OR) for IgE > 100 kU . L(-1) 4.73, 95% confidence intervals (95% CI) = 2.01-11.12, adjusted for specific IgE, sex, age, smoking, forced expiratory volume in one second (FEV1), and area), which did not vary by bronchial responsiveness, The association between total IgE and asthma also occurred among those with negative specific IgE antibodies (OR 18.0; 95% 13.9-120). Individuals with current wheezing and bronchial responsiveness without attacks of asthma also showed an adjusted association with total IgE (OR 4.96; 95% CI 2.32-10.6), which remained for persons without specific IgE (QR 5.86; 95% CI 2.18-1.7). These findings reinforce previous evidence that asthma is associated with increased levels of fetal IgE, even in subjects negative for specific IgE to common aeroallergens.

引用

页码：1880 / 1884

页数：5

共 26 条

[21] GENETIC SUSCEPTIBILITY TO ASTHMA - BRONCHIAL, HYPERRESPONSIVENESS COINHERITED WITH A MAJOR GENE FOR ATOPY [J].

POSTMA, DS ;

BLEECKER, ER ;

AMELUNG, PJ ;

HOLROYD, KJ ;

XU, JF ;

PANHUYSEN, CIM ;

MEYERS, DA ;

LEVITT, RC .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (14) :894-900

[22] EPIDEMIOLOGIC APPROACHES FOR THE IDENTIFICATION OF ASTHMA [J].

SAMET, JM .

CHEST, 1987, 91 (06) :S74-S78

[23] RELATION BETWEEN AIRWAY RESPONSIVENESS AND SERUM IGE IN CHILDREN WITH ASTHMA AND IN APPARENTLY NORMAL-CHILDREN [J].

SEARS, MR ;

BURROWS, B ;

FLANNERY, EM ;

HERBISON, GP ;

HEWITT, CJ ;

HOLDAWAY, MD .

NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (15) :1067-1071

[24] TOWARD A DEFINITION OF ASTHMA FOR EPIDEMIOLOGY [J].

TOELLE, BG ;

PEAT, JK ;

SALOME, CM ;

MELLIS, CM ;

WOOLCOCK, AJ .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 146 (03) :633-637

[25] ASTHMA, HAY-FEVER, AND PHLEGM PRODUCTION ASSOCIATED WITH DISTINCT PATTERNS OF ALLERGY SKIN-TEST REACTIVITY, EOSINOPHILIA, AND SERUM IGE LEVELS - THE NORMATIVE AGING STUDY [J].

TOLLERUD, DJ ;

OCONNOR, GT ;

SPARROW, D ;

WEISS, ST .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 144 (04) :776-781

[26] IDENTIFICATION OF PROFILIN AS A NOVEL POLLEN ALLERGEN - IGE AUTOREACTIVITY IN SENSITIZED INDIVIDUALS [J].

VALENTA, R ;

DUCHENE, M ;

PETTENBURGER, K ;

SILLABER, C ;

VALENT, P ;

BETTELHEIM, P ;

BREITENBACH, M ;

RUMPOLD, H ;

KRAFT, D ;

SCHEINER, O .

SCIENCE, 1991, 253 (5019) :557-560

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