Secretory pathways generating immunosuppressive NKG2D ligands New targets for therapeutic intervention

被引：83

作者：

Baragano Raneros, Aroa ^{[1
]}

Suarez-Alvarez, Beatriz ^{[2
]}

Lopez-Larrea, Carlos ^{[1
,3
]}

机构：

[1] Hosp Univ Cent Asturias, Dept Immunol, Oviedo, Spain

[2] Univ Autonoma Madrid, Inst Invest Sanitaria, Cellular Biol Renal Dis Lab, Fdn Jimenez Diaz, Madrid, Spain

[3] Fdn Renal Inigo Alvarez de Toledo, Madrid, Spain

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 04期

关键词：

NKs; NKG2D; soluble NKG2D ligands; shedding; exosomes; I-RELATED CHAIN; NATURAL-KILLER-CELL; ACTIVATING IMMUNORECEPTOR NKG2D; SOLUBLE UL16-BINDING PROTEIN-2; HUMAN OSTEOSARCOMA CELLS; DOWN-REGULATION; CUTTING EDGE; TUMOR-CELLS; HEPATOCELLULAR-CARCINOMA; CLINICAL-SIGNIFICANCE;

D O I：

10.4161/onci.28497

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Natural Killer Group 2 member D (NKG2D) activating receptor, present on the surface of various immune cells, plays an important role in activating the anticancer immune response by their interaction with stress-inducible NKG2D ligands (NKG2DL) on transformed cells. However, cancer cells have developed numerous mechanisms to evade the immune system via the downregulation of NKG2DL from the cell surface, including the release of NKG2DL from the cell surface in a soluble form. Here, we review the mechanisms involved in the production of soluble NKG2DL (sNKG2DL) and the potential therapeutic strategies aiming to block the release of these immunosuppressive ligands. Therapeutically enabling the NKG2D-NKG2DL interaction would promote immunorecognition of malignant cells, thus abrogating disease progression.

引用

页数：9

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