Sodium tetraalkynylaluminates (1-4), prepared from NaAlH4 and terminal alkynes, cross-couple with aryl bromides in the presence of Pd(0) and Pd(II) catalysts. The reactions take place in boiling THF or DME. The process is applicable to both homo- and heterocyclic aryl bromides and can be used for conversion of polybromo compounds into polyalkynes. The reactions are high yielding and selective, free of undesired homocoupling and hydrogenolysis processes. The reagents selectively react with the ring-bound bromine atoms but do not affect chloro, cyano, triflate, or ester functions.
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New Mexico State Univ, Dept Chem & Biochem MSC 3C, Las Cruces, NM 88003 USANew Mexico State Univ, Dept Chem & Biochem MSC 3C, Las Cruces, NM 88003 USA
Arterburn, JB
Rao, KV
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New Mexico State Univ, Dept Chem & Biochem MSC 3C, Las Cruces, NM 88003 USANew Mexico State Univ, Dept Chem & Biochem MSC 3C, Las Cruces, NM 88003 USA
Rao, KV
Perry, MC
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New Mexico State Univ, Dept Chem & Biochem MSC 3C, Las Cruces, NM 88003 USANew Mexico State Univ, Dept Chem & Biochem MSC 3C, Las Cruces, NM 88003 USA
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GlaxoSmithKline Med Res Ctr, Chem Dev Div, Stevenage SG1 2NY, Herts, EnglandGlaxoSmithKline Med Res Ctr, Chem Dev Div, Stevenage SG1 2NY, Herts, England
Cooke, JWB
Bright, R
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GlaxoSmithKline Med Res Ctr, Chem Dev Div, Stevenage SG1 2NY, Herts, EnglandGlaxoSmithKline Med Res Ctr, Chem Dev Div, Stevenage SG1 2NY, Herts, England
Bright, R
Coleman, MJ
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GlaxoSmithKline Med Res Ctr, Chem Dev Div, Stevenage SG1 2NY, Herts, EnglandGlaxoSmithKline Med Res Ctr, Chem Dev Div, Stevenage SG1 2NY, Herts, England
Coleman, MJ
Jenkins, KP
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GlaxoSmithKline Med Res Ctr, Chem Dev Div, Stevenage SG1 2NY, Herts, EnglandGlaxoSmithKline Med Res Ctr, Chem Dev Div, Stevenage SG1 2NY, Herts, England
机构:
New Mexico State Univ, Dept Chem & Biochem MSC 3C, Las Cruces, NM 88003 USANew Mexico State Univ, Dept Chem & Biochem MSC 3C, Las Cruces, NM 88003 USA
Arterburn, JB
Rao, KV
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h-index: 0
机构:
New Mexico State Univ, Dept Chem & Biochem MSC 3C, Las Cruces, NM 88003 USANew Mexico State Univ, Dept Chem & Biochem MSC 3C, Las Cruces, NM 88003 USA
Rao, KV
Perry, MC
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New Mexico State Univ, Dept Chem & Biochem MSC 3C, Las Cruces, NM 88003 USANew Mexico State Univ, Dept Chem & Biochem MSC 3C, Las Cruces, NM 88003 USA
机构:
GlaxoSmithKline Med Res Ctr, Chem Dev Div, Stevenage SG1 2NY, Herts, EnglandGlaxoSmithKline Med Res Ctr, Chem Dev Div, Stevenage SG1 2NY, Herts, England
Cooke, JWB
Bright, R
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机构:
GlaxoSmithKline Med Res Ctr, Chem Dev Div, Stevenage SG1 2NY, Herts, EnglandGlaxoSmithKline Med Res Ctr, Chem Dev Div, Stevenage SG1 2NY, Herts, England
Bright, R
Coleman, MJ
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机构:
GlaxoSmithKline Med Res Ctr, Chem Dev Div, Stevenage SG1 2NY, Herts, EnglandGlaxoSmithKline Med Res Ctr, Chem Dev Div, Stevenage SG1 2NY, Herts, England
Coleman, MJ
Jenkins, KP
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h-index: 0
机构:
GlaxoSmithKline Med Res Ctr, Chem Dev Div, Stevenage SG1 2NY, Herts, EnglandGlaxoSmithKline Med Res Ctr, Chem Dev Div, Stevenage SG1 2NY, Herts, England