Electrochemical and peroxidase oxidation study of N′-hydroxyguanidine derivatives as NO donors

被引：52

作者：

Cai, TW ^{[1
]}

Xian, M ^{[1
]}

Wang, PG ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(02)00185-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The electrochemical properties of a series of N-substituted-N-hydroxyguanidines were studied. Two oxidation potentials of each compound were obtained by cyclic voltammetry. The E-ox1 values were from 0.51 to 0.62V, while the E-ox2 Values were from 1.14 to 1.81V in acetonitrile solution. Next, their enzymatic controlled NO release abilities were evaluated. All N'-hydroxyguanidines exhibited efficient NO release abilities under the oxidation by horseradish peroxidase in the presence Of H2O2. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1507 / 1510

页数：4

共 36 条

[31] Efficient formation of nitric oxide from selective oxidation of N-aryl N′-hydroxyguanidines by inducible nitric oxide synthase [J].