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The FGF family: biology, pathophysiology and therapy

被引：1470
作者：
Beenken, Andrew [1 ]
Mohammadi, Moosa [1 ]
机构：
[1] NYU, Sch Med, Dept Pharmacol, New York, NY 10016 USA
来源：
NATURE REVIEWS DRUG DISCOVERY | 2009年 / 8卷 / 03期
关键词：
FIBROBLAST-GROWTH-FACTOR; BILE-ACID SYNTHESIS; DOMINANT HYPOPHOSPHATEMIC RICKETS; ENDOTHELIAL-CELL PROLIFERATION; ACTIVATED-RECEPTOR-GAMMA; CHRONIC KIDNEY-DISEASE; SPINAL-CORD REPAIR; PHASE-II TRIAL; AUTOSOMAL-DOMINANT; MULTIPLE-MYELOMA;
D O I：
10.1038/nrd2792
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The family of fibroblast growth factors (FGFs) regulates a plethora of developmental processes, including brain patterning, branching morphogenesis and limb development. Several mitogenic, cytoprotective and angiogenic therapeutic applications of FGFs are already being explored, and the recent discovery of the crucial roles of the endocrine-acting FGF19 subfamily in bile acid, glucose and phosphate homeostasis has sparked renewed interest in the pharmacological potential of this family. This Review discusses traditional applications of recombinant FGFs and small-molecule FGF receptor kinase inhibitors in the treatment of cancer and cardiovascular disease and their emerging potential in the treatment of metabolic syndrome and hypophosphataemic diseases.
引用
收藏
页码：235 / 253
页数：19
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