Curcumin alleviates oxidative stress and inhibits apoptosis in diabetic cardiomyopathy via Sirt1-Foxo1 and PI3K-Akt signalling pathways

被引：400

作者：

Ren, Bin-cheng ^{[1
]}

Zhang, Yu-fei ^{[2
,3
]}

Liu, Shan-shan ^{[1
]}

Cheng, Xiao-jing ^{[1
]}

Yang, Xin ^{[1
]}

Cui, Xiao-guang ^{[1
]}

Zhao, Xin-rui ^{[1
]}

Zhao, Hui ^{[1
]}

Hao, Min-feng ^{[4
]}

Li, Meng-dan ^{[5
]}

Tie, Yuan-yuan ^{[5
]}

Qu, Li ^{[1
]}

Li, Xue-yi ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Dept Rheumatol & Immunol, Affiliated Hosp 2, Xian, Shaanxi, Peoples R China

[2] Northwest A&F Univ, State Key Lab Crop Stress Biol Arid Areas, Yangling, Shaanxi, Peoples R China

[3] Northwest A&F Univ, Coll Life Sci, Yangling, Shaanxi, Peoples R China

[4] Xian Cent Hosp, Dept Neurol, Xian, Peoples R China

[5] Xi An Jiao Tong Univ, Dept Cardiovasc Med, Affiliated Hosp 2, Xian, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2020年 / 24卷 / 21期

基金：

中国国家自然科学基金;

关键词：

apoptosis; curcumin; oxidative stress; PI3K-Akt; Sirt1; type; 2; diabetes; MOLECULAR-MECHANISMS; CARDIAC DYSFUNCTION; HEART-FAILURE; SIRT1; RATS; MELLITUS; OXIDASES; SIRTUINS; FIBROSIS;

D O I：

10.1111/jcmm.15725

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Diabetes is a disorder of glucose metabolism, and over 90% are type 2 diabetes. Diabetic cardiomyopathy (DCM) is one of the type 2 diabetes complications, usually accompanied by changes in myocardial structure and function, together with cardiomyocyte apoptosis. Our study investigated the effect of curcumin on regulating oxidative stress (OS) and apoptosis in DCM. In vivo, diabetes was induced in an experimental rat model by streptozoticin (STZ) together with high-glucose and high-fat (HG/HF) diet feeding. In vitro, H9c2 cardiomyocytes were cultured with high-glucose and saturated free fatty acid palmitate. Curcumin was orally or directly administered to rats or cells, respectively. Streptozoticin -induced diabetic rats showed metabolism abnormalities and elevated markers of OS (superoxide dismutase [SOD], malondialdehyde [MDA], gp91(phox), Cyt-Cyto C), enhanced cell apoptosis (Bax/Bcl-2, Cleaved caspase-3, TUNEL-positive cells), together with reduced Akt phosphorylation and increased Foxo1 acetylation. Curcumin attenuated the myocardial dysfunction, OS and apoptosis in the heart of diabetic rats. Curcumin treatment also enhanced phosphorylation of Akt and inhibited acetylation of Foxo1. These results strongly suggest that apoptosis was increased in the heart of diabetic rats, and curcumin played a role in diabetic cardiomyopathy treatment by modulating the Sirt1-Foxo1 and PI3K-Akt pathways.

引用

页码：12355 / 12367

页数：13

共 45 条

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