Synthesis of a Fluorogenic Analogue of Sphingosine-1-Phosphate and Its Use to Determine Sphingosine-1-Phosphate Lyase Activity

被引：28

作者：

Bedia, Carmen ^{[1
]}

Camacho, Luz ^{[1
]}

Casas, Josefina ^{[1
]}

Abad, Jose Luis ^{[1
]}

Delgado, Antonio ^{[1
,2
]}

Van Veldhoven, Paul R. ^{[3
]}

Fabrias, Gemma ^{[1
]}

机构：

[1] CSIC, Dept Biomed Chem, Inst Quim Avancada Catalunya, ES-08034 Barcelona, Spain

[2] Univ Barcelona, Fac Pharm, Unit Med Chem, CSIC,Associated Unit, E-08028 Barcelona, Spain

[3] Katholieke Univ Leuven, LIPIT, Dept Mol Celbiol, B-3000 Louvain, Belgium

来源：

CHEMBIOCHEM | 2009年 / 10卷 / 05期

关键词：

enzymes; fluorescence; high-throughput screening; retro reactions; sphingolipids; SPHINGOSINE-PHOSPHATE LYASE; DICTYOSTELIUM-DISCOIDEUM; PYRIDOXAL 5'-PHOSPHATE; CHEMOTHERAPY DRUGS; SERUM-ALBUMIN; HUMAN-CELLS; APOPTOSIS; PHOSPHOHYDROLASES; SENSITIVITY; INHIBITION;

D O I：

10.1002/cbic.200800809

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：820 / 822

页数：3