The genome of the blood fluke Schistosoma mansoni

被引：805

作者：

Berriman, Matthew ^{[1
]}

Haas, Brian J. ^{[3
]}

LoVerde, Philip T. ^{[4
,5
]}

Wilson, R. Alan ^{[6
]}

Dillon, Gary P. ^{[6
]}

Cerqueira, Gustavo C. ^{[7
,8
,9
]}

Mashiyama, Susan T. ^{[10
,11
,12
]}

Al-Lazikani, Bissan ^{[13
]}

Andrade, Luiza F. ^{[14
]}

Ashton, Peter D. ^{[4
,5
]}

Aslett, Martin A. ^{[1
]}

Bartholomeu, Daniella C. ^{[3
]}

Blandin, Gaelle ^{[3
]}

Caffrey, Conor R. ^{[10
]}

Coghlan, Avril ^{[15
]}

Coulson, Richard ^{[2
]}

Day, Tim A. ^{[16
]}

Delcher, Art ^{[8
]}

DeMarco, Ricardo ^{[6
,17
,18
]}

Djikeng, Appolinaire ^{[3
]}

Eyre, Tina ^{[1
]}

Gamble, John A. ^{[1
]}

Ghedin, Elodie ^{[3
]}

Gu, Yong ^{[1
]}

Hertz-Fowler, Christiane ^{[1
]}

Hirai, Hirohisha ^{[19
]}

Hirai, Yuriko ^{[19
]}

Houston, Robin ^{[1
]}

Ivens, Alasdair ^{[1
]}

Johnston, David A. ^{[20
]}

Lacerda, Daniela ^{[3
]}

Macedo, Camila D. ^{[7
,9
]}

McVeigh, Paul ^{[16
]}

Ning, Zemin

Oliveira, Guilherme ^{[14
]}

Overington, John P. ^{[2
]}

Parkhill, Julian ^{[1
]}

Pertea, Mihaela ^{[8
]}

Pierce, Raymond J. ^{[21
]}

Protasio, Anna V. ^{[1
]}

Quail, Michael A. ^{[1
]}

Rajandream, Marie-Adele ^{[1
]}

Rogers, Jane ^{[1
]}

Sajid, Mohammed ^{[10
]}

Salzberg, Steven L. ^{[8
,9
]}

Stanke, Mario ^{[22
]}

Tivey, Adrian R. ^{[1
]}

White, Owen ^{[3
]}

Williams, David L. ^{[23
]}

Wortman, Jennifer ^{[3
]}

机构：

[1] Wellcome Trust Sanger Inst, Cambridge CB10 1SD, England

[2] European Bioinformat Inst EMBL, Cambridge CB10 1SD, England

[3] J Craig Venter Inst, Inst Genom Res, Rockville, MD 20850 USA

[4] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA

[5] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA

[6] Univ York, Dept Biol, York YO10 5YW, N Yorkshire, England

[7] Univ Maryland, Dept Mol Genet & Cell Biol, College Pk, MD 20742 USA

[8] Univ Maryland, Ctr Bioinformat & Computat Biol, College Pk, MD 20742 USA

[9] Univ Maryland, Maryland Pathogen Res Inst, College Pk, MD 20742 USA

[10] Univ Calif San Francisco, Sandler Ctr Basic Res Parasit Dis, San Francisco, CA 94158 USA

[11] Univ Calif San Francisco, Dept Biopharmaceut Sci, San Francisco, CA 94158 USA

[12] Univ Calif San Francisco, Dept Pharmaceut Chem, Calif Inst Quantitat Biomed Res QB3, San Francisco, CA 94158 USA

[13] Inst Canc Res, Haddow Labs, Canc Res UK Ctr Canc Therapeut, Sutton SM2 5NG, Surrey, England

[14] Fiocruz MS, Ctr Pesquisas Rene Rachou, BR-30190002 Belo Horizonte, MG, Brazil

[15] Natl Univ Ireland Univ Coll Cork, Dept Microbiol, Cork, Ireland

[16] Iowa State Univ, Dept Biomed Sci, Ames, IA 50011 USA

[17] Univ Sao Paulo, Inst Quim, BR-05508 Sao Paulo, Brazil

[18] Univ Sao Paulo, Inst Fis Sao Carlos, BR-05508 Sao Paulo, Brazil

[19] Kyoto Univ, Primate Res Inst, Aichi 4848506, Japan

[20] Nat Hist Museum, Biomed Parasitol Div, London SW7 5BD, England

[21] Univ Lille 2, INSERM, U547, Inst Pasteur Lille,IFR 142, Lille, France

[22] Univ Gottingen, Inst Mikrobiol & Genet, Abt Bioinformat, D-37077 Gottingen, Germany

[23] Illinois State Univ, Dept Biol Sci, Normal, IL 61790 USA

来源：

NATURE | 2009年 / 460卷 / 7253期

基金：

美国国家卫生研究院; 巴西圣保罗研究基金会; 英国惠康基金; 日本学术振兴会;

关键词：

HIDDEN MARKOV MODEL; EMBRYONIC-DEVELOPMENT; TRYPANOSOMA-CRUZI; GENE; DATABASE; SEQUENCE; RETROTRANSPOSONS; DIVERSITY; DISCOVERY; ALIGNMENT;

D O I：

10.1038/nature08160

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Schistosoma mansoni is responsible for the neglected tropical disease schistosomiasis that affects 210 million people in 76 countries. Here we present analysis of the 363 megabase nuclear genome of the blood fluke. It encodes at least 11,809 genes, with an unusual intron size distribution, and new families of micro-exon genes that undergo frequent alternative splicing. As the first sequenced flatworm, and a representative of the Lophotrochozoa, it offers insights into early events in the evolution of the animals, including the development of a body pattern with bilateral symmetry, and the development of tissues into organs. Our analysis has been informed by the need to find new drug targets. The deficits in lipid metabolism that make schistosomes dependent on the host are revealed, and the identification of membrane receptors, ion channels and more than 300 proteases provide new insights into the biology of the life cycle and new targets. Bioinformatics approaches have identified metabolic chokepoints, and a chemogenomic screen has pinpointed schistosome proteins for which existing drugs may be active. The information generated provides an invaluable resource for the research community to develop much needed new control tools for the treatment and eradication of this important and neglected disease.

引用

页码：352 / U65

页数：9

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