Polymer-bound TBTU as a new solid-supported reagent for peptide synthesis

被引：39

作者：

Chinchilla, R ^{[1
]}

Dodsworth, DJ ^{[1
]}

Nájera, C ^{[1
]}

Soriano, JM ^{[1
]}

机构：

[1] Univ Alicante, Dept Quim Organ, E-03080 Alicante, Spain

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 14期

关键词：

aminium salts; peptides; polymers; coupling reagents;

D O I：

10.1016/S0040-4039(00)00180-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

A new polymer-supported TBTU (P-TBTU) has been prepared from polystyrene-bound 1-hydroxybenzotriazole (P-HOBT) and used efficiently as a solid-supported reagent for peptide-coupling reactions, and is even effective with wet solvents. The P-HOBT can be recovered by simple filtration and reused for the preparation of new P-TBTU. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2463 / 2466

页数：4

共 25 条

[1]

Abdelmoty Iman, 1994, Letters in Peptide Science, V1, P57, DOI 10.1007/BF00126274

[2]

2-mercaptopyridone 1-oxide-based uronium salts:: New peptide coupling reagents [J].