In vitro assessment of chlorhexidine gluconate-impregnated polyurethane foam antimicrobial dressing using zone of inhibition assays

被引：17

作者：

Bhende, S ^{[1
]}

Spangler, D ^{[1
]}

机构：

[1] Ethicon Inc, Corp Microbiol & Sterilizat Sci, Somerville, NJ 08876 USA

来源：

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY | 2004年 / 25卷 / 08期

关键词：

D O I：

10.1086/502458

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

OBJECTIVE: To evaluate an antimicrobial dressing consisting of hydrophilic polyurethane foam with chlorhexidine gluconate for activity against several antibiotic-resistant clinical isolates as well as American Type Culture Collection reference strains using zone of inhibition assays. METHODS: Sterile foam samples with chlorhexidine gluconate and untreated controls were transferred onto inoculated agar plates. Plates were incubated at 35 degreesC to 37 degreesC for 24 hours and examined for zones of inhibition around the foam samples. RESULTS: Polyurethane foam with chlorhexidine gluconate showed antimicrobial activity in vitro against all of the challenge organisms including antibiotic-resistant clinical isolates. CONCLUSION: The data from this in vitro study support the hypothesis that polyurethane foam with chlorhexidine gluconate has an antimicrobial effect against antibiotic-resistant Staphylococcus and Enterococcus species, as well as Candida species

引用

页码：664 / 667

页数：4