Nanotopographic Carbon Nanotube Thin-Film Substrate Freezes Lateral Motion of Secretory Vesicles

被引:19
作者
Zhang, Jing [2 ]
Fu, Dongliang [1 ]
Chan-Park, Mary B. [2 ]
Li, Lain-Jong [1 ]
Chen, Peng [2 ]
机构
[1] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore
[2] Nanyang Technol Univ, Sch Chem & Biomed Engn, Singapore 637457, Singapore
关键词
REFLECTION FLUORESCENCE MICROSCOPY; CHROMAFFIN CELLS; PLASMA-MEMBRANE; EXOCYTOSIS; STIMULATION; BEHAVIOR; NEURONS;
D O I
10.1002/adma.200801586
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Thin-film carbon-nanotube networks can interface with living neuroenclocrine PC12 cells and support their growth and proliferation. Interestingly, as revealed by total-internal-reflection fluorescence microscopy, the nanoroughness created by the carbon-nanotube net physically deforms the 5 nm thick cell membrane with high local curvature and significantly impedes the lateral motion of subplasmalemmal secretory vesicles.
引用
收藏
页码:790 / +
页数:5
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