Ir-catalyzed substitution of propargylic-type esters with enoxysilanes

被引：65

作者：

Matsuda, I ^{[1
]}

Komori, K ^{[1
]}

Itoh, K ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Engn, Dept Mol Design & Engn, Chikusa Ku, Nagoya, Aichi 4648603, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 31期

关键词：

D O I：

10.1021/ja0264089

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Propargylic-type acetates react readily with enoxysilanes in the presence of 1 mol % of [Ir(cod){P(OPh)3}2]OTf activated preliminarily with molecular H2 to give β-alkynyl ketones in high to excellent yields. Substitution at the propargyl carbon proceeds exclusively or selectively in most types of propargylic esters. Alternatively, the formation of the allenyl products is predominant in the reaction of esters, which have two phenyl groups on the propargyl carbon. Copyright © 2002 American Chemical Society.

引用

页码：9072 / 9073

页数：2

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