The Structural and Functional Diversity of Metabolite-Binding Riboswitches

被引:430
作者
Roth, Adam [1 ]
Breaker, Ronald R. [1 ,2 ,3 ]
机构
[1] Yale Univ, Howard Hughes Med Inst, New Haven, CT 06520 USA
[2] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
[3] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA
关键词
aptamer; binding pocket; expression platform; ribozyme; GLYCINE-DEPENDENT RIBOSWITCH; CONTROLS GENE-EXPRESSION; MESSENGER-RNA STRUCTURE; S-MK BOX; LIGAND-BINDING; CRYSTAL-STRUCTURE; COMPARATIVE GENOMICS; THI-BOX; TRANSCRIPTION TERMINATION; MOLECULAR-RECOGNITION;
D O I
10.1146/annurev.biochem.78.070507.135656
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The cellular concentrations of certain metabolites are assiduously monitored to achieve appropriate levels of gene expression. Although proteins have long been known to act as sensors in this capacity, metabolite-binding RNAs, or riboswitches, also play an important role. More than 20 distinct classes of riboswitches have been identified to date, and insights to the molecular recognition strategies of a significant subset of these have been provided by detailed structural studies. This diverse set of metabolite-sensing RNAs is found to exploit a variety of distinct mechanisms to regulate genes that are fundamental to metabolism.
引用
收藏
页码:305 / 334
页数:30
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