A single CH/π weak hydrogen bond governs stability and the photocycle of the photoactive yellow protein

被引：73

作者：

Harigai, Miki ^{[1
]}

Kataoka, Mikio ^{[1
]}

Imamoto, Yasushi ^{[1
]}

机构：

[1] Nara Inst Sci & Technol, Grad Sch Mat Sci, Nara 6300192, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 33期

关键词：

D O I：

10.1021/ja062125v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Importance of the CH/π interaction on the structure and function of the photoactive yellow protein (PYP) was substantiated. Focusing on the phenyl ring of Phe6 adjacent to the alkyl chain of Lys123, the mutants for these amino acid residues were characterized. The results demonstrated that the mutants lacking the π-electron at position 6 or the alkyl chain at position 123 show substantial malfunction. This is a clear example that single CH/π weak interaction plays a crucial role in the normal action of the protein. Copyright © 2006 American Chemical Society.

引用

页码：10646 / 10647

页数：2

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