The NOS/sGC pathway in the rat central nervous system: a microdialysis overview

被引：34

作者：

Pepicelli, O

Raiteri, M

Fedele, E ^{[1
]}

机构：

[1] Univ Genoa, Dipartimento Med Sperimentale, Sezione Farmacol & Tossicol, Genoa, Italy

[2] Univ Genoa, Ctr Eccellenza Ricerca Biomed, Genoa, Italy

来源：

NEUROCHEMISTRY INTERNATIONAL | 2004年 / 45卷 / 06期

关键词：

NO; cGMP; glutamate; GABA; nicotine; aluminium; hyperammonemia; olfactory memory;

D O I：

10.1016/j.neuint.2004.03.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is now well established that nitric oxide is involved in a variety of physiopathological processes in the central nervous system, which mainly result from the interaction of this gaseous molecule with the heme group of soluble guanylyl cyclase and the elevation of intracellular cGMP in target neurons. During the last decade, several studies have monitored extracellular cGMP, by means of intracerebral microdialysis, to investigate in vivo the functioning and modulation of this neurochemical pathway under different experimental conditions and in various brain regions. In this review, we summarise some of the most relevant results obtained in this research field. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：787 / 797

页数：11

共 109 条

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