The versatile role of MSKs in transcriptional regulation

被引：115

作者：

Vermeulen, Linda ^{[1
]}

Vanden Berghe, Wim ^{[1
]}

Beck, Ilse M. E. ^{[1
]}

De Bosscher, Karolien ^{[1
]}

Haegeman, Guy ^{[1
]}

机构：

[1] Univ Ghent, Dept Physiol, LEGEST, B-9000 Ghent, Belgium

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2009年 / 34卷 / 06期

关键词：

NF-KAPPA-B; STRESS-ACTIVATED PROTEIN-KINASE-1; ELEMENT-BINDING PROTEIN; HISTONE H3 PHOSPHORYLATION; S6; KINASE-B; SIGNAL-TRANSDUCTION; GENE-EXPRESSION; C-FOS; MITOGEN; MEDIATE;

D O I：

10.1016/j.tibs.2009.02.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Among the mitogen-activated protein kinase (MAPK) targets, MSKs (mitogen- and stress-activated protein kinases) comprise a particularly interesting protein family. Because MSKs can be activated by both extracellular-signal-regulated kinase and p38 MAPKs, they are activated by many physiological and pathological stimuli. About ten years after their original discovery, they have been recognized as versatile kinases regulating gene transcription at multiple levels. MSKs directly target transcription factors, such as cAMP-response-element-binding protein and nuclear factor-kappa B, thereby enhancing their transcriptional activity. They also induce histone phosphorylation, which is accompanied by chromatin relaxation and facilitated binding of additional regulatory proteins. Here, we review the current knowledge on MSK activation and its molecular targets, focusing on recent insights into the role of MSKs at multiple levels of transcriptional regulation.

引用

页码：311 / 318

页数：8

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