Metabolites from the sponge Plakortis simplex.: II.: Isolation of four bioactive lactone compounds and of a novel related amino acid

被引：56

作者：

Cafieri, F

Fattorusso, E

Taglialatela-Scafati, O

Di Rosa, M

Ianaro, A

机构：

[1] Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] Dipartimento Farmacol Sperimentale, I-80131 Naples, Italy

来源：

TETRAHEDRON | 1999年 / 55卷 / 48期

关键词：

marine metabolites; amino acids; delta-lactones; biosynthesis;

D O I：

10.1016/S0040-4020(99)00866-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Seven lactone metabolites, namely the known plakortones B-D (1-3), the novel plakortones E (4) and F (5), and two novel delta-lactones, named simplactones A (6) and B (7), have been isolated from the Caribbean sponge Plakortis simplex, and their structures characterized by spectroscopic and chemical means. In addition, the unprecedented amino acid 8 has been isolated from the same source, and a hypothesis of its biogenetic relationship with simplactones is herein reported. Plakortones B-F and compound 8 exhibited in vitro cytotoxic activity on WEHI 164, murine fibrosarcoma cell line. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

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收藏

页码：13831 / 13840

页数：10

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