Eligibility for treatment and angiographic features at the early stage of exudative age related macular degeneration

被引:25
作者
Haddad, WM [1 ]
Coscas, G [1 ]
Soubrane, G [1 ]
机构
[1] Univ Paris 12, Dept Ophthalmol, Creteil, France
关键词
D O I
10.1136/bjo.86.6.663
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Aims: To determine the eligibility for loser photocoagulation treatment or for photodynamic therapy (PDT) with verteporfin in eyes at the earliest stage (first month of symptoms) of exudative age related macular degeneration (AMD) based on fluorescein anglographic (FA) features; to evaluate the potential contribution of indocyanine green angiography (ICG-A) for occult choroidal neovascularisation (CNV) at this stage. Methods: Retrospective review of 252 consecutive patients (269 eyes) examined within the first month of symptoms of exudative AMD. Results: On FA, 97 eyes (36%) had classic CNV alone. Occult CNV associated with fibrovascular retinal pigment epithelium detachments (PEDs) was observed in 71 eyes (26%) and without fibrovascular PED in 101 eyes (38%). 91 eyes (34%) met the Macular Photocoagulation Study criteria for laser photocoagulation. 53 eyes (20%) met the Verteporfin In PDT (VIP) or Treatment of AMD with PDT (TAP) studies criteria. By ICG-A, occult CNV was visualised as focal spots in 49% of eyes examined within, 15 days v 32% of eyes examined between 16 and 30 days after the onset of symptoms (p=0.07). 8.5% of late staining plaques disclosed in eyes examined within 15 days were combined with focal spots v 36% in eyes examined between 16 and 30 days (p<0.0 1), Conclusions: Early examination of eyes with exudative AMD would allow the treatment of 471. of eyes. 60% of eyes with subfoveal CNV would be eligible for PDT with verteporfin. Up to half of eyeswith occult CNV would be converted by ICG-A into well delineated focal spots.
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页码:663 / 669
页数:7
相关论文
共 41 条
[1]  
[Anonymous], 1982, Br J Ophthalmol, V66, P745
[2]  
[Anonymous], 1991, Arch Ophthalmol, V109, P1220
[3]  
Arnold J, 2001, AM J OPHTHALMOL, V131, P541
[4]   AN INTERNATIONAL CLASSIFICATION AND GRADING SYSTEM FOR AGE-RELATED MACULOPATHY AND AGE-RELATED MACULAR DEGENERATION [J].
BIRD, AEC ;
BRESSLER, NM ;
BRESSLER, SB ;
CHISHOLM, IH ;
COSCAS, G ;
DAVIS, MD ;
DEJONG, PTVM ;
KLAVER, CCW ;
KLEIN, BEK ;
KLEIN, R ;
MITCHELL, P ;
SARKS, JP ;
SARKS, SH ;
SOURBANE, G ;
TAYLOR, HR ;
VINGERLING, JR .
SURVEY OF OPHTHALMOLOGY, 1995, 39 (05) :367-374
[5]   CLINICAL-APPLICATION OF DIGITAL INDOCYANINE GREEN VIDEOANGIOGRAPHY IN SENILE MACULAR DEGENERATION [J].
BOTTONI, FG ;
AANDEKERK, AL ;
DEUTMAN, AF .
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 1994, 232 (08) :458-468
[6]  
Bressler NM, 1999, ARCH OPHTHALMOL-CHIC, V117, P1329
[7]  
BRESSLER NM, 1987, ARCH OPHTHALMOL-CHIC, V105, P209
[8]  
CAPT RP, 2001, INVEST OPHTH VIS SCI, V42, pS440
[9]   CLINICOPATHOLOGICAL CORRELATION OF CHOROIDAL NEOVASCULARIZATION DEMONSTRATED BY INDOCYANINE GREEN ANGIOGRAPHY IN A PATIENT WITH RETENTION OF GOOD VISION FOR ALMOST 4 YEARS [J].
CHANG, TS ;
FREUND, KB ;
DELACRUZ, Z ;
YANNUZZI, LA ;
GREEN, WR .
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 1994, 14 (02) :114-124
[10]   PERIFOVEAL LASER TREATMENT FOR SUBFOVEAL CHOROIDAL NEW VESSELS IN AGE-RELATED MACULAR DEGENERATION - RESULTS OF A RANDOMIZED CLINICAL-TRIAL [J].
COSCAS, G ;
SOUBRANE, G ;
RAMAHEFASOLO, C ;
FARDEAU, C .
ARCHIVES OF OPHTHALMOLOGY, 1991, 109 (09) :1258-1265