Apoptotic pathways in ischemic acute renal failure

被引:113
作者
Kaushal, GP
Basnakian, AG
Shah, SV
机构
[1] Univ Arkansas Med Sci, Dept Med, Div Nephrol, Little Rock, AR 72205 USA
[2] Cent Arkansas Vet Healthcare Syst, Little Rock, AR USA
关键词
cell death; endonucleases; mitochondria caspases; renal tubular epithelial cells; acute renal failure;
D O I
10.1111/j.1523-1755.2004.761_6.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The study of cell death has emerged as an important and exciting area of research in cell biology. Although two kinds of cell death, apoptosis and necrosis, are recognized, one of the major advances in our understanding of cell death has been the recognition that the pathways traditionally associated with apoptosis may be very critical in the form of cell injury associated with necrosis. Renal tubular epithelial cell injury from ischemia has been generally regarded as a result of necrotic form of cell death. We briefly describe recent evidence indicating that pathways generally associated with apoptosis, including endonuclease activation, role of mitochondria and caspases, are important in renal tubular injury. It is likely that the cascades that lead to apoptotic or necrotic mode of cell death are activated almost simultaneously and may share some common pathways.
引用
收藏
页码:500 / 506
页数:7
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