Neurotransmitter receptor/G-protein mediated signal transduction in Alzheimer's disease brain

被引：14

作者：

Cowburn, RF

Fowler, CJ

ONeill, C

机构：

[1] UMEA UNIV, DEPT PHARMACOL, S-90187 UMEA, SWEDEN

[2] NATL UNIV IRELAND UNIV COLL CORK, DEPT BIOCHEM, CORK, IRELAND

来源：

NEURODEGENERATION | 1996年 / 5卷 / 04期

关键词：

adenylyl cyclase; Alzheimer's disease; beta-amyloid; G-protein; phospholipase C; protein kinase C; neurotransmission;

D O I：

10.1006/neur.1996.0067

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent evidence suggests that the neurochemical pathology of Alzheimer's disease includes severe disruptions of the neurotransmitter receptor/G-protein mediated phosphatidylinositol hydrolysis and adenylyl cyclase signal transduction pathways. The present article briefly reviews evidence from postmortem studies describing disruptions to these systems and speculates as to the importance of these changes in terms of contributing to disease pathology and limiting the success of neurotransmitter replacement strategies. (C) 1996 Academic Press Limited

引用

页码：483 / 488

页数：6

共 37 条

[1] A NEUROCHEMICAL APPROACH FOR STUDYING RESPONSE TO ACETYLCHOLINE IN ALZHEIMERS-DISEASE [J].