Mansoquinone: Isolation and structure elucidation of new antibacterial aromatic polyketides from terrestrial Streptomyces Sp Eg5

被引：15

作者：

Abdelfattah, Mohamed S. ^{[1
]}

机构：

[1] Helwan Univ, Fac Sci, Dept Chem, Cairo, Egypt

来源：

NATURAL PRODUCT RESEARCH | 2009年 / 23卷 / 03期

关键词：

terrestrial Streptomyces Sp; aromatic polyketides; anthraquinone; antibacterial activities; ANTHRAQUINONE;

D O I：

10.1080/14786410801961550

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The cultivation of terrestrial Streptomyces Sp. Eg5 delivered two new aromatic polyketides, 2-butyryl-1,8-dihydroxy-3-methylanthraquinone (2), or mansoquinone, and 2-acetyl-1,8-dihydroxy-3-methyl-anthra-quinone (3) along with the known 2-ethyl-1,8-dihydroxy-3-methylanthraquinone (1). The structure of mansoquinone (2) was elucidated using detailed spectral (1H and 13C NMR, 1H-1H COSY, HSQC, HMBC and HRMS) analysis. This is the first report of the isolation of 3 from natural source. Mansoquinone (2) exhibited moderate antibacterial activities against Escherichia coli, Bacillus subtilis and Staphylococcus aureus.

引用

页码：212 / 218

页数：7

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