Molecular diversity of anticoagulants from haematophagous animals

被引：73

作者：

Koh, Cho Yeow

Kini, R. Manjunatha ^{[1
,2
]}

机构：

[1] Natl Univ Singapore, Prot Sci Lab, Dept Biol Sci, Fac Sci, Sci Dr 4, Singapore 117543, Singapore

[2] Virginia Commonwealth Univ, Med Coll Virginia, Med Ctr, Dept Biochem, Richmond, VA 23298 USA

来源：

THROMBOSIS AND HAEMOSTASIS | 2009年 / 102卷 / 03期

关键词：

Anticoagulants; haematophagous animals; structure-function relationships; exogenous factors; molecular diversity; AMINO-ACID-SEQUENCE; COAGULATION-FACTOR-XA; HUMAN ALPHA-THROMBIN; ORNITHODOROS-SAVIGNYI ACARI; HEPARIN-BINDING EXOSITE; LONE STAR TICK; SALIVARY-GLANDS; CRYSTAL-STRUCTURE; BLOOD-COAGULATION; BOOPHILUS-MICROPLUS;

D O I：

10.1160/TH09-04-0221

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To obtain blood meals, haematophagous animals are armed with potent pharmacological molecules to overcome several of their hosts' response systems. Among them, a large number of exogenous anticoagulants which target the haemostatic system have been identified and characterised. Studies on these anticoagulants have expanded our knowledge on the blood coagulation system, and provided a valuable source of antithrombotic therapeutic agents. Advances in genomic, transcriptomic, structural and proteomic tools greatly accelerated the discovery and analysis of the exogenous anticoagulants in recent years. The molecular diversity observed in these molecules is huge and is constantly expanding. In this review, we will provide an overview on the structure, function and mechanism of the exogenous anticoagulants from haematophagous animals and rationalise their molecular diversity.

引用

页码：437 / 453

页数：17

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