Palladium-Catalyzed Benzylation of Heterocyclic Aromatic Compounds

被引：104

作者：

Lapointe, David ^{[1
]}

Fagnou, Keith ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6J7, Canada

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 18期

基金：

加拿大自然科学与工程研究理事会;

关键词：

SITE-SELECTIVE SP(2); DIRECT ARYLATION; ALKYL-HALIDES; HETEROAROMATIC-COMPOUNDS; COUPLING REACTIONS; N-OXIDES; FUNCTIONALIZATION; DERIVATIVES; ACTIVATION; ARENES;

D O I：

10.1021/ol901689q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Broadly applicable palladium-catalyzed heteroarene benzylation reactions are described with a focus on the most challenging heterocyclic classes under traditional benzylation techniques such as sulfur-containing heterocycles and those bearing functional groups that would be incompatible with reactions requiring Lewis acids and/or strong bases.

引用

页码：4160 / 4163

页数：4

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