机构:Univ Texas, SW Med Sch, Cecil H & Ida Green Ctr Reprod Biol Sci, Dallas, TX 75390 USA
Zhao, GQ
Garbers, DL
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Univ Texas, SW Med Sch, Cecil H & Ida Green Ctr Reprod Biol Sci, Dallas, TX 75390 USAUniv Texas, SW Med Sch, Cecil H & Ida Green Ctr Reprod Biol Sci, Dallas, TX 75390 USA
Garbers, DL
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机构:
[1] Univ Texas, SW Med Sch, Cecil H & Ida Green Ctr Reprod Biol Sci, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Sch, Howard Hughes Med Inst, Dallas, TX 75390 USA
[3] Univ Texas, SW Med Sch, Dept Pharmacol, Dallas, TX 75390 USA
Understanding the mechanisms by which the germline is induced and maintained should lead to a broader understanding of the means by which pluripotency is acquired and maintained. In this review, two major aspects of male germ cell development are discussed: underlying mechanisms for induction and maintenance of primordial germ cells and the basic signaling pathways that determine spermatogonial cell fate.