Clinical pharmacology of HIV protease inhibitors: focus on saquinavir, indinavir, and ritonavir

被引:75
作者
Hoetelmans, RMW
Meenhorst, PL
Mulder, JW
Burger, DM
Koks, CHW
Beijnen, JH
机构
[1] SLOTERVAART HOSP, DEPT INTERNAL MED, NL-1066 EC AMSTERDAM, NETHERLANDS
[2] UNIV NIJMEGEN HOSP, DEPT CLIN PHARM, NL-6500 HB NIJMEGEN, NETHERLANDS
来源
PHARMACY WORLD & SCIENCE | 1997年 / 19卷 / 04期
关键词
clinical pharmacology; HIV infection; protease inhibitor; ritonavir; saquinavir;
D O I
10.1023/A:1008629608556
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In this review the clinical pharmacology of HIV protease inhibitors, a new class of antiretroviral drugs, is discussed. After considering HIV protease function and structure, the development of inhibitors of HIV protease is presented. Three protease inhibitors are reviewed in more detail: saquinavir, indinavir, and ritonavir. Clinical trial results with these agents are evaluated. Furthermore, adverse effects, resistance, dosage and administration, clinical pharmacokinetics, pharmacokinetic-pharmacodynamic relationships, and drug interactions are discussed.
引用
收藏
页码:159 / 175
页数:17
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