IFITM proteins - cellular inhibitors of viral entry

被引：101

作者：

Smith, S. E. ^{[1
]}

Weston, S. ^{[2
]}

Kellam, P. ^{[1
,3
]}

Marsh, M. ^{[2
]}

机构：

[1] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England

[2] UCL, MRC Lab Mol Cell Biol, London WC1E 6BT, England

[3] UCL, Div Infect & Immun, MRC UCL Ctr Med Mol Virol, London WC1E 6BT, England

来源：

CURRENT OPINION IN VIROLOGY | 2014年 / 4卷

基金：

英国医学研究理事会; 英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

INDUCED TRANSMEMBRANE PROTEIN-3; ANTIVIRAL ACTIVITY; S-PALMITOYLATION; HIV-1; INFECTION; VIRUS; RESTRICTS; GENE; RESISTANCE; TETHERIN; FAMILY;

D O I：

10.1016/j.coviro.2013.11.004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Interferon inducible transmembrane (IFITM) proteins are a recently discovered family of cellular anti-viral proteins that restrict the replication of a number of enveloped and non-enveloped viruses. IFITM proteins are located in the plasma membrane and endosomal membranes, the main portals of entry for many viruses. Biochemical and membrane fusion studies suggest IFITM proteins have the ability to inhibit viral entry, possibly by modulating the fluidity of cellular membranes. Here we discuss the IFITM proteins, recent work on their mode of action, and future directions for research.

引用

页码：71 / 77

页数：7

共 40 条

[1] The Dispanins: A Novel Gene Family of Ancient Origin That Contains 14 Human Members [J].

Almen, Markus Sallman ;

Bringeland, Nathalie ;

Fredriksson, Robert ;

Schioth, Helgi B. .

PLOS ONE, 2012, 7 (02)

[2] The Antiviral Effector IFITM3 Disrupts Intracellular Cholesterol Homeostasis to Block Viral Entry [J].

Amini-Bavil-Olyaee, Samad ;

Choi, Youn Jung ;

Lee, Jun Han ;

Shi, Mude ;

Huang, I-Chueh ;

Farzan, Michael ;

Jung, Jae U. .

CELL HOST & MICROBE, 2013, 13 (04) :452-464

[3] Interferon-inducible Transmembrane Protein 3 (IFITM3) Restricts Reovirus Cell Entry [J].

Anafu, Amanda A. ;

Bowen, Christopher H. ;

Chin, Christopher R. ;

Brass, Abraham L. ;

Holm, Geoffrey H. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (24) :17261-17271

[4] Interferon-induced Transmembrane Protein 3 Is a Type II Transmembrane Protein [J].

Bailey, Charles C. ;

Kondur, Hema R. ;

Huang, I-Chueh ;

Farzan, Michael .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (45) :32184-32193

[5] Ifitm3 Limits the Severity of Acute Influenza in Mice [J].

Bailey, Charles C. ;

Huang, I-Chueh ;

Kam, Christina ;

Farzan, Michael .

PLOS PATHOGENS, 2012, 8 (09)

[6] The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus [J].

Brass, Abraham L. ;

Huang, I-Chueh ;

Benita, Yair ;

John, Sinu P. ;

Krishnan, Manoj N. ;

Feeley, Eric M. ;

Ryan, Bethany J. ;

Weyer, Jessica L. ;

van der Weyden, Louise ;

Fikrig, Erol ;

Adams, David J. ;

Xavier, Ramnik J. ;

Farzan, Michael ;

Elledge, Stephen J. .

CELL, 2009, 139 (07) :1243-1254

[7] Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1 family proteins [J].

Chutiwitoonchai, Nopporn ;

Hiyoshi, Masateru ;

Hiyoshi-Yoshidomi, Yuka ;

Hashimoto, Michihiro ;

Tokunaga, Kenzo ;

Suzu, Shinya .

MICROBES AND INFECTION, 2013, 15 (04) :280-290

[8] Evolutionary conflicts between viruses and restriction factors shape immunity [J].

Duggal, Nisha K. ;

Emerman, Michael .

NATURE REVIEWS IMMUNOLOGY, 2012, 12 (10) :687-695

[9] IFITM3 restricts the morbidity and mortality associated with influenza [J].

Everitt, Aaron R. ;

Clare, Simon ;

Pertel, Thomas ;

John, Sinu P. ;

Wash, Rachael S. ;

Smith, Sarah E. ;

Chin, Christopher R. ;

Feeley, Eric M. ;

Sims, Jennifer S. ;

Adams, David J. ;

Wise, Helen M. ;

Kane, Leanne ;

Goulding, David ;

Digard, Paul ;

Anttila, Verneri ;

Baillie, J. Kenneth ;

Walsh, Tim S. ;

Hume, David A. ;

Palotie, Aarno ;

Xue, Yali ;

Colonna, Vincenza ;

Tyler-Smith, Chris ;

Dunning, Jake ;

Gordon, Stephen B. ;

Smyth, Rosalind L. ;

Openshaw, Peter J. ;

Dougan, Gordon ;

Brass, Abraham L. ;

Kellam, Paul .

NATURE, 2012, 484 (7395) :519-U146

[10] IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry [J].

Feeley, Eric M. ;

Sims, Jennifer S. ;

John, Sinu P. ;

Chin, Christopher R. ;

Pertel, Thomas ;

Chen, Li-Mei ;

Gaiha, Gaurav D. ;

Ryan, Bethany J. ;

Donis, Ruben O. ;

Elledge, Stephen J. ;

Brass, Abraham L. .

PLOS PATHOGENS, 2011, 7 (10)

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