Genotoxic potential of estrogens

被引：37

作者：

Hundal, BS ^{[1
]}

Dhillon, VS ^{[1
]}

Sidhu, IS ^{[1
]}

机构：

[1] IVF RES CTR,NEW DELHI,INDIA

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 1997年 / 389卷 / 2-3期

关键词：

estrogen; chromosome aberration; sister chromatid exchange (SCE); micronucleus; S9; mix; human lymphocyte; bone marrow cell; Ames Salmonella assay; host-mediated assay;

D O I：

10.1016/S1383-5718(96)00144-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A genotoxicity evaluation of three commonly used estrogens - ethinyl estradiol, cyclotriol and cyclodiol was undertaken using short-term in vitro and in vivo assays. None of the drugs caused significantly increased or decreased number of His(+) mutants to appear in the Ames Salmonella assay, either with or without S9 mix or in a modified host-mediated version of this assay. However, the clastogenic potential of these drugs became evident from the increased number or chromosome aberrations and sister chromatid exchanges (SCEs) induced by these drugs in human lymphocyte cultures both in the presence and absence of S9 mix. Increased frequencies of micronuclei and of sister chromatid exchanges in mice confirmed their clastogenic potential.

引用

页码：173 / 181

页数：9

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