IN-VITRO AND IN-VIVO GENOTOXICITY EVALUATION OF HORMONAL DRUGS V MESTRANOL

被引：23

作者：

DHILLON, VS ^{[1
]}

SINGH, JR ^{[1
]}

SINGH, H ^{[1
]}

KLER, RS ^{[1
]}

机构：

[1] GURU NANAK DEV UNIV, DEPT HUMAN GENET, HUMAN GENET LAB, AMRITSAR 143005, PUNJAB, INDIA

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY | 1994年 / 322卷 / 03期

关键词：

MESTRANOL; AMES TEST; HUMAN LYMPHOCYTES; MICRONUCLEI; HOST-MEDIATED ASSAY; SISTER CHROMATID EXCHANGE; CHROMOSOMAL ABERRATION;

D O I：

10.1016/0165-1218(94)90004-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genotoxicity of a widely used estrogen, Mestranol, was undertaken using in vitro, in vivo and host-mediated assay with bacteria as indicator organism. Analyses of chromosome aberrations and sister chromatid exchanges (SCEs) in human lympocytes and chromosome aberrations, micronuclei and sister chromatid exchanges (SCEs) in bone-marrow cells of mice showed the drug to be capable of attacking the genetic material. However, both Ames Salmonella/S9 assay with and without S9 mix and host-mediated assay using same tester strains of Salmonella, did not show any significant increase/decrease in the His(+) revertants.

引用

页码：173 / 183

页数：11

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