From PTK-STAT signaling to caspase expression and apoptosis induction

被引：33

作者：

Fu, XY ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06520 USA

来源：

CELL DEATH AND DIFFERENTIATION | 1999年 / 6卷 / 12期

关键词：

protein tyrosine kinase; STAT; apoptosis induction; caspase; gene regulation;

D O I：

10.1038/sj.cdd.4400613

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cell growth and survival can be regulated by cytokine-induced signals. Nevertheless, the molecular mechanisms of signal transduction from cytokine receptors to mediators of cell growth and apoptosis are not well characterized. STAT (signal transducer and activator of transcription) proteins can be activated by protein tyrosine kinases (PTK) in response to a variety of cytokines. We have shown that STAT activation induces expression of caspases which may cause cells undergo apoptosis, A hypothesis is proposed that PTK-STAT signaling pathways can regulate induction of apoptosis in response to cytokines and other extracellular signals.

引用

页码：1201 / 1208

页数：8

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