Pregnancy outcome is not affected by antiphospholipid antibody status in women referred for in vitro fertilization

被引:50
作者
Chilcott, IT
Margara, R
Cohen, H
Rai, R
Skull, J
Pickering, W
Regan, L
机构
[1] Imperial Coll Med St Marys, Dept Obstet & Gynecol, Sch Med, London W2 1PG, England
[2] UCL Hosp, NHS Trust, London, England
关键词
antiphospholipid antibodies; anti-beta 2 glycoprotein I antibodies; in vitro fertilization; pregnancy outcome;
D O I
10.1016/S0015-0282(99)00585-3
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To determine the prevalence of antiphospholipid (aPL) and anti-beta 2 glycoprotein I (anti-beta 2-GPI) antibodies in women referred for IVF and to prospectively evaluate the effect of these antibodies on IVF outcome. Design: Prospective observational study. Setting: A university hospital and IVF unit. Patient(s): Three hundred eighty consecutive women referred for IVF. Intervention(s): Blood samples taken before commencement of IVF cycles were tested for the presence of aPL (lupus anticoagulant [LA], anticardiolipin [aCL], and antiphosphatidyl serine antibodies [aPS]) and anti-beta 2-GPI antibodies. Main Outcome Measure(s): Antibody prevalence, pregnancy rates, and live birth rates. Result(s): Of the total 380 women, 89 tested persistently positive for aPL (23.4%). None of 176 women tested for IgG aPS antibodies had a positive titer. Only 3.3% (11 of 329) tested positive for anti-beta 2-GPI antibodies. Pregnancy rate, live birth rate, gestational age at delivery, and birth weight were not affected by aPL status. Conclusion(s): Although women referred for IVF have a high prevalence of aPL, these antibodies do not affect the outcome of treatment. Screening women undergoing IVF for aPL is not justified. (C) 2000 by American Society for Reproductive Medicine.
引用
收藏
页码:526 / 530
页数:5
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