Cellular mechanisms regulating human melanogenesis

被引：309

作者：

Park, H. Y. ^{[1
]}

Kosmadaki, M. ^{[1
]}

Yaar, M. ^{[1
]}

Gilchrest, B. A. ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Dept Dermatol, Boston, MA 02118 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2009年 / 66卷 / 09期

关键词：

Melanogenesis; melanosomes; UV; DNA damages; and melanocytes; NERVE GROWTH-FACTOR; MELANOCYTE-STIMULATING-HORMONE; CULTURED HUMAN MELANOCYTES; PROTEIN-KINASE-C; NECROSIS-FACTOR-ALPHA; TYROSINASE-RELATED PROTEIN; TRANSCRIPTION FACTOR MITF; NITRIC-OXIDE SYNTHASE; DNA-DAMAGE RESPONSES; HUMAN-SKIN;

D O I：

10.1007/s00018-009-8703-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The major differentiated function of melanocytes is the synthesis of melanin, a pigmented heteropolymer that is synthesized in specialized cellular organelles termed melanosomes. Mature melanosomes are transferred to neighboring keratinocytes and are arranged in a supranuclear cap, protecting the DNA against incident ultraviolet light (UV) irradiation. The synthesis and distribution of melanin in the epidermis involves several steps: transcription of melanogenic proteins, melanosome biogenesis, sorting of melanogenic proteins into the melanosomes, transport of melanosomes to the tips of melanocyte dendrites and finally transfer into keratinocytes. These events are tightly regulated by a variety of paracrine and autocrine factors in response to endogenous and exogenous stimuli, principally UV irradiation.

引用

页码：1493 / 1506

页数：14

共 188 条

[61] Melanin content and MC1R function independently affect UVR-induced DNA damage in cultured human melanocytes [J].

Hauser, Jennifer E. ;

Kadekaro, Ana Luisa ;

Kavanagh, Renny J. ;

Wakamatsu, Kazumasa ;

Terzieva, Silva ;

Schwemberger, Sandy ;

Babcock, George ;

Rao, M. B. ;

Ito, Shosuke ;

Abdel-Malek, Zalfa A. .

PIGMENT CELL RESEARCH, 2006, 19 (04) :303-314

[62] Melanocortin-1-receptor gene and sun sensitivity in individuals without red hair [J].

Healy, E ;

Flannagan, N ;

Ray, A ;

Todd, C ;

Jackson, IJ ;

Matthews, JNS ;

Birch-Machin, MA ;

Rees, JL .

LANCET, 2000, 355 (9209) :1072-1073

[63] Biogenesis of pigment granules: a sensitive way to regulate melanocyte function [J].

Hearing, VJ .

JOURNAL OF DERMATOLOGICAL SCIENCE, 2005, 37 (01) :3-14

[64] MAMMALIAN TYROSINASE - THE CRITICAL REGULATORY CONTROL POINT IN MELANOCYTE PIGMENTATION [J].

HEARING, VJ ;

JIMENEZ, M .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 1987, 19 (12) :1141-1147

[65]

HECK DE, 1992, J BIOL CHEM, V267, P21277

[66] MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes [J].

Hemesath, TJ ;

Price, ER ;

Takemoto, C ;

Badalian, T ;

Fisher, DE .

NATURE, 1998, 391 (6664) :298-301

[67] Genomic analysis of the Microphthalmia locus and identification of the MITF-J/Mitf-J isoform [J].

Hershey, CL ;

Fisher, DE .

GENE, 2005, 347 (01) :73-82

[68] KINESIN ASSOCIATES WITH ANTEROGRADELY TRANSPORTED MEMBRANOUS ORGANELLES INVIVO [J].

HIROKAWA, N ;

SATOYOSHITAKE, R ;

KOBAYASHI, N ;

PFISTER, KK ;

BLOOM, GS ;

BRADY, ST .

JOURNAL OF CELL BIOLOGY, 1991, 114 (02) :295-302

[69] Membrane dynamics and cell polarity: the role of sphingolipids [J].

Hoekstra, D ;

Maier, O ;

van der Wouden, JM ;

Slimane, TA ;

van Ijzendoorn, SCD .

JOURNAL OF LIPID RESEARCH, 2003, 44 (05) :869-877

[70] IDENTIFICATION AND CHARACTERIZATION OF A NOVEL MEMBER OF THE NERVE GROWTH-FACTOR BRAIN-DERIVED NEUROTROPHIC FACTOR FAMILY [J].

HOHN, A ;

LEIBROCK, J ;

BAILEY, K ;

BARDE, YA .

NATURE, 1990, 344 (6264) :339-341

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