Molecular epidemiology of dengue type 3 virus in Brazil and Paraguay, 2002-2004

被引：50

作者：

Aquino, Victor H.

Anatriello, Elen

Goncalves, Paula F.

da Silva, Eliana V.

Vasconcelos, Pedro F. C.

Vieira, Deusylene S.

Batista, Weber C.

Bobadilla, Maria L.

Vazquez, Cynthia

Moran, Mirian

Figueiredo, Luiz T. M.

机构：

[1] USP, Fac Ciencias Farmaceut Ribeirao Preto, Virol Lab, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP, Brazil

[2] USP, Fac Med Ribeirao Preto, Ctr Pesquisa Virol, BR-14040903 Ribeirao Preto, SP, Brazil

[3] Inst Evandro Chagas, Belem, Para, Brazil

[4] Ctr Pesquisa Med Trop, Porto Velho, RO, Brazil

[5] Ministerio Salud Publ, Lab Cent Salud Publ, Asuncion, Paraguay

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2006年 / 75卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.4269/ajtmh.2006.75.710

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We studied the molecular epidemiology of dengue virus type 3 (DENV-3) in Brazil and Paraguay by analyzing the 5' and 3' untranslated regions (5' and 3'UTRs) and the E protein gene of viruses isolated between 2002 and 2004. Both 5' and 3'UTRs were highly conserved. However, the 3'UTR of two isolates from Brazil contained eight nucleotide deletions compared with the remaining 26 viruses. Phylogenetic analyses suggested that DENV-3 was introduced into Brazil from the Caribbean Islands at least twice and into Paraguay from Brazil at least three times.

引用

页码：710 / 715

页数：6

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