Isomer-specific effects of conjugated linoleic acid (CLA) on adiposity and lipid metabolism

被引:180
作者
Evans, ME
Brown, JM
McIntosh, MK [1 ]
机构
[1] Univ N Carolina, Grad Program Nutr, Greensboro, NC 27402 USA
[2] Emory Univ, Dept Med Endocrinol, Atlanta, GA 30322 USA
关键词
conjugated linoleic acid (CLA); adiposity; lipid metabolism; antiobesity; preadipocytes; adipocytes;
D O I
10.1016/S0955-2863(02)00211-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Isomers of conjugated linoleic acid (CLA), unsaturated fatty acids found in ruminant meats and dairy products, have been shown to reduce adiposity and alter lipid metabolism in animal, human, and cell culture studies. In particular, dietary CLA decreases body fat and increases lean body mass in certain rodents, chickens, and pigs, depending on the isomer, dose, and duration of treatment. However, the effects of CLA on human adiposity are conflicting because these studies have used different mixtures and levels of CLA isomers and diverse subject populations. Potential antiobesity mechanisms of CLA include decreased preadipocyte proliferation and differentiation into mature adipocytes, decreased fatty acid and triglyceride synthesis, and increased energy expenditure, lipolysis, and fatty acid oxidation. This review will address the current research on CLA's effects on human and animal adiposity and lipid metabolism as well as potential mechanism(s) responsible for CLA's antiobesity properties. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:508 / 516
页数:9
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