Immunological memory to viral infections

被引：159

作者：

Welsh, RM ^{[1
]}

Selin, LK ^{[1
]}

Szomolanyi-Tsuda, E ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01655 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2004年 / 22卷

关键词：

T cells; B cells; antibody; cytotoxicity; vaccine;

D O I：

10.1146/annurev.immunol.22.012703.104527

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The purpose of immunological memory is to protect the host from reinfection, to control persistent infections, and, through maternal antibody, to protect the host's immunologically immature offspring from primary infections. Immunological memory is an exclusive property of the acquired immune system, where in the presence of CD4 T cell help, T cells and B cells clonally expand and differentiate to provide effector systems that protect the host from pathogens. Here we describe how T and B cell memory is generated in response to virus infections and how these cells respond when the host is infected again by similar or different viruses.

引用

页码：711 / 743

页数：35

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