Palladium(II)-mediated cascade carbonylative annulation of o-alkynyl-phenols on silyl linker-based macrobeads:: A combinatorial synthesis of a 2,3-disubstituted benzo[b]furan library

被引：59

作者：

Liao, Y

Reitman, M

Zhang, Y

Fathi, R

Yang, Z

机构：

[1] Harvard Univ, Sch Med, Harvard Inst Chem & Cell Biol, Boston, MA 02115 USA

[2] VivoQuest Inc, Valley Cottage, NY 10989 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 15期

关键词：

D O I：

10.1021/ol020111y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A palladium(II)-mediated cascade carbonylative annulation of o-alkynylphenols was achieved successfully on silyl linker-based macrobeads, which led to an efficient combinatorial synthesis of a 2,3-disubstituted benzo[b]furan library.

引用

页码：2607 / 2609

页数：3

共 18 条

[11] RADIOFREQUENCY ENCODED COMBINATORIAL CHEMISTRY
NICOLAOU, KC
XIAO, XY
PARANDOOSH, Z
SENYEI, A
NOVA, MP
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1995, 34 (20): : 2289 - 2291
[12] Target-oriented and diversity-oriented organic synthesis in drug discovery
Schreiber, SL
[J]. SCIENCE, 2000, 287 (5460) : 1964 - 1969
[13] Split-pool synthesis of 1,3-dioxanes leading to arrayed stock solutions of single compounds sufficient for multiple phenotypic and protein-binding assays
Sternson, SM
Louca, JB
Wong, JC
Schreiber, SL
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (08) : 1740 - 1747
[14] An alkylsilyl-tethered, high-capacity solid support amenable to diversity-oriented synthesis for one-bead, one-stock solution chemical genetics
Tallarico, JA
Depew, KM
Pelish, HE
Westwood, NJ
Lindsley, CW
Shair, MD
Schreiber, SL
Foley, MA
[J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 2001, 3 (03): : 312 - 318
[15] TAMARU Y, 1979, TETRAHEDRON LETT, V16, P1401
[16] Synthesis of the diazonamide A macrocyclic core via a Dieckmann-type cyclization
Vedejs, E
Zajac, MA
[J]. ORGANIC LETTERS, 2001, 3 (16) : 2451 - 2454
[17] WAGNER H, 1984, PLANTA MED, P370
[18] REGIOSELECTIVE INTRODUCTION OF CARBON-3 SUBSTITUENTS TO 5-ALKYL-7-METHOXY-2-PHENYLBENZO[B]FURANS - SYNTHESIS OF A NOVEL ADENOSINE-A1-RECEPTOR LIGAND AND ITS DERIVATIVES
YANG, Z
LIU, HB
LEE, CM
CHANG, HM
WONG, HNC
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (26) : 7248 - 7257

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