Brief Report: Fatal Case of Deer Tick Virus Encephalitis

被引：82

作者：

Tavakoli, Norma P. ^{[1
,2
]}

Wang, Heng ^{[1
]}

Dupuis, Michelle ^{[1
]}

Hull, Rene ^{[1
]}

Ebel, Gregory D. ^{[3
]}

Gilmore, Emily J. ^{[4
,6
]}

Faust, Phyllis L. ^{[5
,6
]}

机构：

[1] New York City Dept Hlth, Wadsworth Ctr, Albany, NY USA

[2] SUNY Albany, Sch Publ Hlth, Dept Biomed Sci, Albany, NY 12222 USA

[3] Univ New Mexico, Sch Med, Dept Pathol, Albuquerque, NM 87131 USA

[4] Columbia Univ, Dept Neurol, New York, NY USA

[5] Columbia Univ, Dept Pathol & Cell Biol, New York, NY USA

[6] New York Presbyterian Hosp, New York, NY USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2009年 / 360卷 / 20期

关键词：

POWASSAN VIRUS; BORNE ENCEPHALITIS; NEW-ENGLAND; INFECTION; TRANSMISSION; PHYLOGENY; REGION;

D O I：

10.1056/NEJMoa0806326

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Deer tick virus is related to Powassan virus, a tickborne encephalitis virus. A 62-year-old man presented with a meningoencephalitis syndrome and eventually died. Analyses of tissue samples obtained during surgery and at autopsy revealed a widespread necrotizing meningoencephalitis. Nucleic acid was extracted from formalin-fixed tissue, and the presence of deer tick virus was verified on a flavivirus-specific polymerase-chain-reaction (PCR) assay, followed by sequence confirmation. Immunohistochemical analysis with antisera specific for deer tick virus identified numerous immunoreactive neurons, with prominent involvement of large neurons in the brain stem, cerebellum, basal ganglia, thalamus, and spinal cord. This case demonstrates that deer tick virus can be a cause of fatal encephalitis.

引用

页码：2099 / 2107

页数：9

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