QT interval and mortality from coronary artery disease

Abnormalities in the QT interval can be divided into 3 types, prolongation of the QT interval, increases in the dispersion of the QT interval, and abnormalities in the heart rate dependent behavior of the QT interval. Abnormalities may be found in short or long-term recordings. Prolongation of the QT interval may reflect factors associated with an adverse prognosis in coronary disease and may in itself be arrhythmogenic. The data to date suggest that there is an association between adverse prognosis and QT interval prolongation in coronary disease, both before and after acute myocardial infarctions. This relationship is weak, however, and is not clinically useful. The data as to whether increased QT dispersion postmyocardial infarction relates to adverse prognosis is weak because there is no convincing evidence yet. If there is a relationship it is weak. Abnormalities in the rate dependent behavior of the QT interval are widely found, but as no large scale prospective study with mortality as an endpoint has yet been undertaken the significance of rate dependent abnormalities is uncertain. The widespread introduction of beat-to-beat QT analysis of 24 hour Holter tapes may take QT intervalology into the realm of clinical practice. (C) 2000 by W.B. Saunders Company.