Macrophage migration inhibitory factor and glucocorticoid sensitivity

被引：53

作者：

Aeberli, D. ^{[1
]}

Leech, M. ^{[1
]}

Morand, E. F. ^{[1
]}

机构：

[1] Monash Univ, Med Ctr, Ctr Inflammatory Dis, Melbourne, Vic 3168, Australia

来源：

RHEUMATOLOGY | 2006年 / 45卷 / 08期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

MIF; glucocorticoids; steroid sparing; rheumatoid arthritis;

D O I：

10.1093/rheumatology/kel142

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucocorticoids (GCs) are widely used in the treatment of inflammatory diseases including rheumatoid arthritis (RA). Treatment with GC is associated with significant dose-dependent side-effects. The pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) has emerged in recent years as a candidate factor which could regulate GC sensitivity. MIF is induced by GC, and is able to override anti-inflammatory actions of GCs. In this review, we summarize the pro-inflammatory actions of MIF with respect to RA, describe the interactions between MIF and GC and examine new evidence, which identifies MIF as a specific target for steroid sparing.

引用

页码：937 / 943

页数：7

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