Plakins: Goliaths that link cell junctions and the cytoskeleton

被引：132

作者：

Jefferson, JJ

Leung, CL

Liem, RKH

机构：

[1] Columbia Univ Coll Phys & Surg, Dept Pathol, New York, NY 10032 USA

[2] Columbia Univ Coll Phys & Surg, Dept Anat & Cell Biol, New York, NY 10032 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1425

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Plakins comprise a family of proteins that crosslink cytoskeletal filaments and attach them to membrane-associated complexes at cell junctions. They were originally found associated with intermediate filaments and were believed to function primarily in maintaining epithelial tissue integrity. However, new plakins with unique isoforms that are enormous in size have been identified in the past few years. These new plakins have highlighted further functions in all the cytoskeletal networks, as well as in non-epithelial cells.

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页码：542 / 553

页数：12

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