Ah receptor ligands and tumor promotion: survival of neoplastic cells

被引：53

作者：

Schwarz, M ^{[1
]}

Buchmann, A ^{[1
]}

Stinchcombe, S ^{[1
]}

Kalkuhl, A ^{[1
]}

Bock, KW ^{[1
]}

机构：

[1] Univ Tubingen, Inst Toxicol, D-72074 Tubingen, Germany

来源：

TOXICOLOGY LETTERS | 2000年 / 112卷

关键词：

hepatocarcinogenesis; apoptosis; cell proliferation; dioxin; TCDD;

D O I：

10.1016/S0378-4274(99)00247-7

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

A number of agonists of the aryl hydrocarbon or dioxin receptor (AhR) are potent tumor promoters in rodent liver. The prototype compound is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Tumor promotion by TCDD is likely to be AhR-mediated. Tumor promoters may affect the rate of division, terminal differentiation or death (apoptosis) of tumor precursor cells. The present paper reviews some of the effects of TCDD on liver cell homeostasis that have been observed under diverse experimental settings and discusses some of the possible underlying mechanisms. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：69 / 77

页数：9

共 53 条

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