Planar cell polarity in moving cells: think globally, act locally

被引：108

作者：

Davey, Crystal F. ^{[1
]}

Moens, Cecilia B. ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Basic Sci, B2-159,1100 Fairview Ave N, Seattle, WA 98109 USA

来源：

DEVELOPMENT | 2017年 / 144卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Cell migration; Planar cell polarity; Planar polarity; CONVERGENT EXTENSION MOVEMENTS; NEURAL-TUBE CLOSURE; FACIAL BRANCHIOMOTOR NEURONS; BREAST-CANCER PROGRESSION; NONCANONICAL WNT PATHWAY; GROWTH CONE GUIDANCE; XENOPUS-LAEVIS; ZEBRAFISH GASTRULATION; CREST MIGRATION; INNER-EAR;

D O I：

10.1242/dev.122804

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

The planar cell polarity (PCP) pathway is best known for its role in polarizing epithelial cells within the plane of a tissue but it also plays a role in a range of cell migration events during development. The mechanism by which the PCP pathway polarizes stationary epithelial cells is well characterized, but how PCP signaling functions to regulate more dynamic cell behaviors during directed cell migration is much less understood. Here, we review recent discoveries regarding the localization of PCP proteins in migrating cells and their impact on the cell biology of collective and individual cell migratory behaviors.

引用

页码：187 / 200

页数：14

共 162 条

[1]

Wnt-Signaling and Planar Cell Polarity Genes Regulate Axon Guidance Along the Anteroposterior Axis in C. elegans [J].

Ackley, Brian D. .

DEVELOPMENTAL NEUROBIOLOGY, 2014, 74 (08) :781-796

[2]

A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression [J].

Anastas, J. N. ;

Biechele, T. L. ;

Robitaille, M. ;

Muster, J. ;

Allison, K. H. ;

Angers, S. ;

Moon, R. T. .

ONCOGENE, 2012, 31 (32) :3696-3708

[3]

Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation [J].

Andre, Philipp ;

Song, Hai ;

Kim, Wantae ;

Kispert, Andreas ;

Yang, Yingzi .

DEVELOPMENT, 2015, 142 (08) :1516-1527

[4]

Coordinating cell and tissue behavior during zebrafish neural tube morphogenesis [J].

Araya, Claudio ;

Ward, Laura C. ;

Girdler, Gemma C. ;

Miranda, Miguel .

DEVELOPMENTAL DYNAMICS, 2016, 245 (03) :197-208

[5]

Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation [J].

Bertet, C ;

Sulak, L ;

Lecuit, T .

NATURE, 2004, 429 (6992) :667-671

[6]

The zebrafish trilobite gene is essential for tangential migration of branchiomotor neurons [J].

Bingham, S ;

Higashijima, S ;

Okamoto, H ;

Chandrasekhar, A .

DEVELOPMENTAL BIOLOGY, 2002, 242 (02) :149-160

[7]

Multicellular rosette formation links planar cell polarity to tissue morphogenesis [J].

Blankenship, J. Todd ;

Backovic, Stephanie T. ;

Sanny, Justina S. P. ;

Weitz, Ori ;

Zallen, Jennifer A. .

DEVELOPMENTAL CELL, 2006, 11 (04) :459-470

[8]

Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia [J].

Borovina, Antonia ;

Superina, Simone ;

Voskas, Daniel ;

Ciruna, Brian .

NATURE CELL BIOLOGY, 2010, 12 (04) :407-U242

[9]

Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling [J].

Boutros, M ;

Paricio, N ;

Strutt, DI ;

Mlodzik, M .

CELL, 1998, 94 (01) :109-118

[10]

The Nance-Horan syndrome protein encodes a functional WAVE homology domain (WHD) and is important for co-ordinating actin remodelling and maintaining cell morphology [J].

Brooks, Simon P. ;

Coccia, Margherita ;

Tang, Hao R. ;

Kanuga, Naheed ;

Machesky, Laura M. ;

Bailly, Maryse ;

Cheetham, Michael E. ;

Hardcastle, Alison J. .

HUMAN MOLECULAR GENETICS, 2010, 19 (12) :2421-2432

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