Cell death in the nervous system

被引：486

作者：

Bredesen, Dale E.

Rao, Rammohan V.

Mehlen, Patrick

机构：

[1] Buck Inst Age Res, Novato, CA 94945 USA

[2] Univ Calif San Francisco, San Francisco, CA 94143 USA

[3] Univ Lyon, Ctr Leon Berard, Apoptosis Canc & Dev Lab, F-69008 Lyon, France

来源：

NATURE | 2006年 / 443卷 / 7113期

关键词：

ENDOPLASMIC-RETICULUM STRESS; CYTOCHROME-C RELEASE; AMYOTROPHIC-LATERAL-SCLEROSIS; APOPTOSIS-INDUCING FACTOR; TRANSGENIC MOUSE MODEL; MITOCHONDRIAL FISSION; HUNTINGTONS-DISEASE; NEURONAL DEATH; NEURODEGENERATIVE DISEASES; CASPASE ACTIVATION;

D O I：

10.1038/nature05293

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease trigger neuronal cell death through endogenous suicide pathways. Surprisingly, although the cell death itself may occur relatively late in the course of the degenerative process, the mediators of the underlying cell-death pathways have shown promise as potential therapeutic targets.

引用

收藏

页码：796 / 802

页数：7

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