Polyketide library synthesis: Iterative assembly of extended polypropionates using (R)- and (S)-1-(benzyloxy)-2-methylpentan-3-one.

被引：24

作者：

Paterson, I

Scott, JP

机构：

[1] University Chemical Laboratory, Cambridge CB2 1EW, Lensfield Road

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 42期

关键词：

D O I：

10.1016/S0040-4039(97)01751-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The heptapropionates 5 and 20 were synthesised by iterative application of the boron-mediated aldol reaction of ethyl ketone (R)-4 and subsequent reduction. Polyketide library diversification was realised by varying the ketone configuration and substitution in the aldol bond constructions. (C) 1997 Elsevier Science Ltd.

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页码：7441 / 7444

页数：4

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