Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients

被引：127

作者：

Huang, Fengming ^{[1
]}

Guo, Jing ^{[2
,3
]}

Zou, Zhen ^{[1
]}

Liu, Jun ^{[4
,5
]}

Cao, Bin ^{[6
]}

Zhang, Shuyang ^{[7
,8
,9
]}

Li, Hui ^{[6
]}

Wang, Wei ^{[1
]}

Sheng, Miaomiao ^{[1
]}

Liu, Song ^{[1
]}

Pan, Jingcao ^{[10
]}

Bao, Changjun ^{[11
]}

Zeng, Mei ^{[12
]}

Xiao, Haixia ^{[13
]}

Qian, Guirong ^{[2
,3
]}

Hu, Xinjun ^{[2
,3
]}

Chen, Yuanting ^{[2
,3
]}

Chen, Yu ^{[2
,3
]}

Zhao, Yan ^{[1
]}

Liu, Qiang ^{[1
]}

Zhou, Huandi ^{[1
]}

Zhu, Jindong ^{[1
]}

Gao, Hainv ^{[2
,3
]}

Yang, Shigui ^{[2
,3
]}

Liu, Xiaoli ^{[2
,3
]}

Zheng, Shufa ^{[2
,3
]}

Yang, Jiezuan ^{[2
,3
]}

Diao, Hongyan ^{[2
,3
]}

Cao, Hongcui ^{[2
,3
]}

Wu, Ying ^{[4
]}

Zhao, Min ^{[4
]}

Tan, Shuguang ^{[4
]}

Guo, Dan ^{[7
,8
]}

Zhao, Xiliang ^{[8
,9
]}

Ye, Yicong ^{[8
,9
]}

Wu, Wei ^{[8
,9
]}

Xu, Yingchun ^{[7
,8
,14
]}

Penninger, Josef M. ^{[15
]}

Li, Dangsheng ^{[16
]}

Gao, George F. ^{[3
,4
,5
,17
]}

Jiang, Chengyu ^{[1
,7
,8
]}

Li, Lanjuan ^{[2
,3
]}

机构：

[1] Chinese Acad Med Sci, Tsinghua Univ, Peking Union Med Coll, Inst Basic Med Sci,Dept Biochem,State Key Lab Med, Beijing 100005, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 1, Coll Med, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310003, Zhejiang, Peoples R China

[3] Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China

[4] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China

[5] Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China

[6] Capital Med Univ, Beijing Chao Yang Hosp, Beijing Inst Resp Med, Dept Infect Dis & Clin Microbiol, Beijing 100020, Peoples R China

[7] Peking Union Med Coll Hosp, Peking Union Med Coll, Ctr Translat Med, Beijing 100730, Peoples R China

[8] Chinese Acad Med Sci, Beijing 100730, Peoples R China

[9] Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Cardiol, Beijing 100730, Peoples R China

[10] Hangzhou Ctr Dis Control & Prevent, Hangzhou 310021, Zhejiang, Peoples R China

[11] Jiangsu Prov Ctr Dis Control & Prevent, Nanjing 210009, Jiangsu, Peoples R China

[12] Fudan Univ, Childrens Hosp, Shanghai 200032, Peoples R China

[13] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Lab Prot Engn & Vaccines, Tianjin 300308, Peoples R China

[14] Peking Union Med Coll Hosp, Peking Union Med Coll, Clin Biobank, Beijing 100730, Peoples R China

[15] Austrian Acad Sci, Inst Mol Biotechnol, IMBA, A-1030 Vienna, Austria

[16] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China

[17] China CDC, Chinese Ctr Dis Control & Prevent, Off Director Gen, Beijing 102206, Peoples R China

来源：

NATURE COMMUNICATIONS | 2014年 / 5卷

关键词：

A H7N9 VIRUS; CONVERTING ENZYME; ALDOSTERONE SYSTEM; HUMAN INFECTIONS; CRUCIAL ROLE; LUNG INJURY; APACHE-II; RENIN; EXPRESSION; PROTECTS;

D O I：

10.1038/ncomms4595

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A novel influenza A (H7N9) virus of avian origin emerged in eastern China in the spring of 2013. This virus causes severe disease in humans, including acute and often lethal respiratory failure. As of January 2014, 275 cases of H7N9-infected patients had been reported, highlighting the urgency of identifying biomarkers for predicting disease severity and fatal outcomes. Here, we show that plasma levels of angiotensin II, a major regulatory peptide of the renin-angiotensin system, are markedly elevated in H7N9 patients and are associated with disease progression. Moreover, the sustained high levels of angiotensin II in these patients are strongly correlated with mortality. The predictive value of angiotensin II is higher than that of C-reactive protein and some clinical parameters such as the PaO2/FiO(2) ratio (partial pressure of arterial oxygen to the fraction of inspired oxygen). Our findings indicate that angiotensin II is a biomarker for lethality in flu infections.

引用

页数：7

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